Localization and Characterization of the Human ADP-Ribosylation Factor 5 (ARF5) Gene
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چکیده
منابع مشابه
Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin.
Mammalian ADP-ribosylation factors (ARFs), approximately 20-kDa guanine nucleotide-binding proteins that stimulate cholera toxin ADP-ribosyltransferase activity, were grouped into three classes based on deduced amino acid sequence. Human ARF 1, a class I ARF, is identical with its bovine counterpart, has a distinctive pattern of tissue and developmental expression, and is encoded by a approxima...
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Phospholipase D (PLD) has been implicated in a variety of cellular processes including vesicular transport, the respiratory burst, and mitogenesis. PLD1, first cloned from human, is activated by small GTPases such as ADP-ribosylation factor (ARF) and RhoA. Rodent PLD2, which is approximately 50% identical to PLD1 has recently been cloned from mouse embryo (Colley, W., Sung, T., Roll, R., Jenco,...
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Antigen-evoked influx of extracellular Ca 2 1 into mast cells may occur via store-operated Ca 2 1 channels called calcium release–activated calcium (CRAC) channels. In mast cells of the rat basophilic leukemia cell line (RBL-2H3), cholera toxin (CT) potentiates antigen-driven uptake of 45 Ca 2 1 through cAMP-independent means. Here, we have used perforated patch clamp recording at physiological...
متن کاملLocalization of ADP-ribosylation factor domain protein 1 (ARD1) in lysosomes and Golgi apparatus.
ADP-ribosylation factor domain protein 1 (ARD1) is a member of the ADP ribosylation factor (ARF) family of guanine nucleotide-binding proteins that differs from other ARFs by the presence of a 46-kDa amino-terminal extension which acts as a GTPase-activating protein (GAP) for its ARF domain. Similar to ARF GAPs, the GAP domain of ARD1 contains a zinc finger motif and arginine residues that are ...
متن کاملDifferential localization and function of ADP-ribosylation factor-6 in anergic human T cells: a potential marker for their identification.
Anergy is a state of immunologic tolerance in which T cells are viable but incapable of responding to antigenic stimulation. Recent data indicate that anergic cells have a distinct gene expression program that determines their unique function. In this study we show that anergic human T cells selectively express the small GTPase ADP-ribosylation factor-6 (ARF6), which is involved in membrane tra...
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ژورنال
عنوان ژورنال: Genomics
سال: 1997
ISSN: 0888-7543
DOI: 10.1006/geno.1997.4689